Hassler, Matthew: search on Z-Library

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1

A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system

Alterman, Julia F., Godinho, Bruno M. D. C., Hassler, Matthew R., Ferguson, Chantal M., Echeverria, Dimas, Sapp, Ellen, Haraszti, Reka A., Coles, Andrew H., Conroy, Faith, Miller, Rachael, Roux, Loic,

Journal:

Nature Biotechnology

Year:

2019

Language:

english

File:

PDF, 3.18 MB

english, 2019

2

RNA synthesis via dimer and trimer phosphoramidite block coupling

Matthew Hassler, Yi Qiao Wu, N. Mallikarjuna Reddy, Tak Hang Chan, Masad J. Damha

Journal:

Tetrahedron Letters

Year:

2011

Language:

english

File:

PDF, 634 KB

english, 2011

3

RNAi modulation of placental sFLT1 for the treatment of preeclampsia

Turanov, Anton A, Lo, Agnes, Hassler, Matthew R, Makris, Angela, Ashar-Patel, Ami, Alterman, Julia F, Coles, Andrew H, Haraszti, Reka A, Roux, Loic, Godinho, Bruno M D C, Echeverria, Dimas, Pears, Suz

Journal:

Nature Biotechnology

Year:

2018

Language:

english

File:

PDF, 3.49 MB

english, 2018

4

Novel Cluster and Monomer-Based GalNAc Structures Induce Effective Uptake of siRNAs in Vitro and in Vivo

Sharma, Vivek Kumar, Osborn, Maire F., Hassler, Matthew, Echeverria, Dimas, Ly, Socheata, Ulashchik, Egor, Martynenko-Makaev, Yury, Shmanai, Vadim V, Zatsepin, Timofei S., Khvorova, Anastasia, Watts,

Journal:

Bioconjugate Chemistry

Year:

2018

Language:

english

File:

PDF, 953 KB

english, 2018

5

Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain

Alterman, Julia F, Hall, Lauren M, Coles, Andrew H, Hassler, Matthew R, Didiot, Marie-Cecile, Chase, Kathryn, Abraham, Jasmin, Sottosanti, Emily, Johnson, Emily, Sapp, Ellen, Osborn, Maire F, Difiglia

Journal:

Molecular Therapy — Nucleic Acids

Year:

2015

Language:

english

File:

PDF, 2.64 MB

english, 2015

6

An orthogonal photolabile linker for the complete “on-support” synthesis/fast deprotection/hybridization of RNA

Lietard, Jory, Hassler, Matthew R., Fakhoury, Johans, Damha, Masad J.

Journal:

Chemical Communications

Year:

2014

Language:

english

File:

PDF, 1.85 MB

english, 2014

7

Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles

Haraszti, Reka Agnes, Miller, Rachael, Didiot, Marie-Cecile, Biscans, Annabelle, Alterman, Julia F., Hassler, Matthew R., Roux, Loic, Echeverria, Dimas, Sapp, Ellen, DiFiglia, Marian, Aronin, Neil, Kh

Journal:

Molecular Therapy

Year:

2018

Language:

english

File:

PDF, 1.22 MB

english, 2018

8

Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo

Biscans, Annabelle, Coles, Andrew, Haraszti, Reka, Echeverria, Dimas, Hassler, Matthew, Osborn, Maire, Khvorova, Anastasia

Journal:

Nucleic Acids Research

Year:

2018

Language:

english

File:

PDF, 12.99 MB

english, 2018

9

Cardiovascular safety evaluations assessment in exercise stress and heart failure models

Craig R. Hassler, Matthew Coffee, Michael Hawk, Michael Stonerook, Matthew Ellinger, Thomas Vinci, Brandon Wood, Robert Lordo, Robert Hamlin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2008

Language:

english

File:

PDF, 54 KB

english, 2008

10

Effects of ambient temperature upon cardiovascular parameters in primates

Brian M. Roche, Tom Vinci, Jeremy Smith, Eric Benson, Brandon Borders, Matthew Ellinger, Craig Hassler, Brandon Wood, Kevin Hicks

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2010

Language:

english

File:

PDF, 55 KB

english, 2010

11

Cell Type Impacts Accessibility of mRNA to Silencing by RNA Interference

Ferguson, Chantal M., Echeverria, Dimas, Hassler, Matthew, Ly, Socheata, Khvorova, Anastasia

Journal:

Molecular Therapy — Nucleic Acids

Year:

2020

File:

PDF, 1.29 MB

2020

12

Corrigendum: Taking charge of siRNA delivery

Khvorova, Anastasia, Osborn, Maire F, Hassler, Matthew R

Journal:

Nature Biotechnology

Year:

2015

Language:

english

File:

PDF, 96 KB

english, 2015

13

Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing

Mir, Aamir, Alterman, Julia F., Hassler, Matthew R., Debacker, Alexandre J., Hudgens, Edward, Echeverria, Dimas, Brodsky, Michael H., Khvorova, Anastasia, Watts, Jonathan K., Sontheimer, Erik J.

Journal:

Nature Communications

Year:

2018

Language:

english

File:

PDF, 1.06 MB

english, 2018

14

Analysis of ECG waveforms collected from telemetered guinea pigs

Eric Benson, Brian Roche, Tom Vinci, Matthew Ellinger, Jeremy Smith, Brandon Wood, Alecia Peppers, Jessica Wise, Craig Hassler

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2009

Language:

english

File:

PDF, 52 KB

english, 2009

15

The Branched-Chain Aminotransferase Proteins: Novel Redox Chaperones for Protein Disulfide Isomerase–Implications in Alzheimer's Disease

El Hindy, Maya, Hezwani, Mohammed, Corry, David, Hull, Jonathon, El Amraoui, Farah, Harris, Matthew, Lee, Christopher, Forshaw, Thomas, Wilson, Andrew, Mansbridge, Abbe, Hassler, Martin, Patel, Vinood

Journal:

Antioxidants & Redox Signaling

Year:

2014

Language:

english

File:

PDF, 2.00 MB

english, 2014

16

Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain

Nikan, Mehran, Osborn, Maire F, Coles, Andrew H, Godinho, Bruno MDC, Hall, Lauren M, Haraszti, Reka A, Hassler, Matthew R, Echeverria, Dimas, Aronin, Neil, Khvorova, Anastasia

Journal:

Molecular Therapy — Nucleic Acids

Year:

2016

Language:

english

File:

PDF, 3.12 MB

english, 2016

17

Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay

Godinho, Bruno M.D.C., Gilbert, James W., Haraszti, Reka A., Coles, Andrew H., Biscans, Annabelle, Roux, Loic, Nikan, Mehran, Echeverria, Dimas, Hassler, Matthew, Khvorova, Anastasia

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2017

Language:

english

File:

PDF, 644 KB

english, 2017

18

Discovery of 2-substituted benzoxazole carboxamides as 5-HT3 receptor antagonists

Zhicai Yang, David J. Fairfax, Jun-Ho Maeng, Liaqat Masih, Alexander Usyatinsky, Carla Hassler, Soshanna Isaacson, Kevin Fitzpatrick, Russell J. DeOrazio, Jianqing Chen, James P. Harding, Matthew Ishe

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 391 KB

english, 2010

19

Coarse-grained terrigenous sediment deposition on continental rise drifts: A record of Plio-Pleistocene glaciation on the Antarctic Peninsula

Ellen A. Cowan, Claus-Dieter Hillenbrand, Lauren E. Hassler, Matthew T. Ake

Journal:

Palaeogeography, Palaeoclimatology, Palaeoecology

Year:

2008

Language:

english

File:

PDF, 1.61 MB

english, 2008

20

TARGETING APOLIPOPROTEIN E WITH TISSUE SPECIFIC SMALL INTERFERING RNAS

Ferguson, Chantal, Grigorenko, Anastasia, Alterman, Julia, Hassler, Matthew, Coles, Andrew, Echeverria, Dimas, Rogaev, Evgeny, Khvorova, Anastasia

Journal:

Alzheimer's & Dementia

Year:

2019

Language:

english

File:

PDF, 617 KB

english, 2019

21

Design and Synthesis of 4-Heteroaryl 1,2,3,4-Tetrahydroisoquinolines as Triple Reuptake Inhibitors

Liu, Shuang, Zha, Congxiang, Nacro, Kassoum, Hu, Min, Cui, Wenge, Yang, Yuh-Lin, Bhatt, Ulhas, Sambandam, Aruna, Isherwood, Matthew, Yet, Larry, Herr, Michael T., Ebeltoft, Sarah, Hassler, Carla, Flem

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 858 KB

english, 2014

22

Enantioselective Synthesis of Benzyl (1 S ,2 R ,4 R )-4-( tert -Butoxycarbonylamino)-2-(hydroxymethyl)cyclohexylcarbamate Using an Iodolactamization As the Key Step

Campbell, Carlton L., Hassler, Carla, Ko, Soo S., Voss, Matthew E., Guaciaro, Michael A., Carter, Percy H., Cherney, Robert J.

Journal:

Journal of Organic Chemistry

Year:

2009

Language:

english

File:

PDF, 758 KB

english, 2009

23

Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs

Osborn, Maire F., Alterman, Julia F., Nikan, Mehran, Cao, Hong, Didiot, Marie C., Hassler, Matthew R., Coles, Andrew H., Khvorova, Anastasia

Journal:

Nucleic Acids Research

Year:

2015

Language:

english

File:

PDF, 2.91 MB

english, 2015

24

2â²-O-Methyl at 20-mer Guide Strand 3â² Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA

Davis, Sarah M., Sousa, Jacquelyn, Vangjeli, Lorenc, Hassler, Matthew R., Echeverria, Dimas, Knox, Emily, Turanov, Anton A., Alterman, Julia F., Khvorova, Anastasia

Journal:

Molecular Therapy — Nucleic Acids

Year:

2020

File:

PDF, 2.40 MB

2020

25

Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo

Hassler, Matthew R, Turanov, Anton A, Alterman, Julia F, Haraszti, Reka A, Coles, Andrew H, Osborn, Maire F, Echeverria, Dimas, Nikan, Mehran, Salomon, William E, Roux, Loïc, Godinho, Bruno M D C, Dav

Journal:

Nucleic Acids Research

Year:

2018

Language:

english

File:

PDF, 7.50 MB

english, 2018

26

Taking charge of siRNA delivery

Khvorova, Anastasia, Osborn, Maire F, Hassler, Matthew R

Journal:

Nature Biotechnology

Year:

2014

Language:

english

File:

PDF, 1.33 MB

english, 2014

27

Oligonucleotide Synthesis Using Ionic Liquids as Soluble Supports

Donga, Robert A., Hassler, Matthew, Chan, Tak-Hang, Damha, Masad J.

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2007

Language:

english

File:

PDF, 98 KB

english, 2007

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